Temporal experience and its radical alteration in schizophrenia have been one of the central objects of investigation in phenomenological psychopathology. Various phenomenologically oriented researchers have argued that the change in the mode of temporal experience present in schizophrenia can foreground its psychotic symptoms of delusion. This paper aims to further the development of such a phenomenological investigation by highlighting a much-neglected aspect of schizophrenic temporal experience, i.e., its non-emotional affective characteristic. In this paper, it denotes the type of an experience (...) wherein an afflicted individual experiences a pervasive pull or attraction coming from the past, present, and future. By employing Husserl’s account of affection, I argue that such an affectively prominent temporal experience is not yet another abnormality that happens to be present in schizophrenia. Instead, it is indicative of the core disturbance that underpins the schizophrenic temporal mode of experience. I identify such a disturbance as ‘affective modification dysfunction’ and employ it as a core concept with which I synthesize and organise heterogeneous components of schizophrenic temporal experience in their conceptual unity. For the sake of clear description, I organise those components into the following categories: 1.) Time Stop 2.) Ante-festum 3.) Déjà vu/vécu and 4.) Time Fragmentation. I conclude by demonstrating how approaching schizophrenic temporal experience from its affective dimension can further help us better understand its pre-psychotic phase known to precipitate schizophrenic primary delusion, i.e., delusional mood. (shrink)

ADP‐ribosylation is a post‐translational modification catalyzed by writer enzymes – ADP‐ribosyltransferases. The modification is part of many signaling events, can modulate the function and stability of target proteins, and often results in the recruitment of reader proteins that bind to the ADP‐ribosyl groups. Erasers are integral actors in these signaling events and reverse the modification. ADP‐ribosylation can be targeted with therapeutics and many inhibitors against writers exist, with some being in clinical use. Inhibitors against readers and erasers are sparser and (...) development of these has gained momentum only in recent years. Drug discovery has been hampered by the lack of specific tools, however many significant advances in the methods have recently been reported. We discuss assays used in the field with a focus on methods allowing efficient identification of small molecule inhibitors and profiling against enzyme families. While human proteins are focused, the methods can be also applied to bacterial toxins and virus encoded erasers that can be targeted to treat infectious diseases in the future. (shrink)

This article examines how growing fears, insecurities and uncertainties during the COVID-19 pandemic have prompted an emotional distance from others. The aim is to explore how global solidarity and nationalism are challenged and constructed as collective emotional processes concerning ‘others’. Drawing on social theories of emotions during crises and emotions towards others, this study looks at policy decisions around vaccines and health services and their associated emotions in the context of Korea, which has a relatively small migrant population and a (...) short history of supporting people in lower-income countries. The study finds that the COVID-19 pandemic has strengthened nationalism, both ethnic nationalism and cosmopolitan nationalism. This points to the need to highlight global norms such as human rights and justice and cultivate foundational emotions such as empathy and compassion. This article suggests paying attention to the role of emotions in generating othering practices and developing global solidarity. (shrink)

There is an evident lack of rigorous frameworks for making sense of the role and status of spirituality and religion in organizations and organizing, in particular from the perspective of spiritual philosophies of the social. This paper suggests that the philosophy of Plato and his modern follower, political theorist Eric Voegelin could offer a viable perspective for understanding organizational spirituality in its metaphysical, political and ethical contexts. Essential for such a philosophical reflection is the postulation of the transcendental realm as (...) the ultimate reality that provides the fullest templates for order, knowledge and ethicality. It is argued, in the footsteps of Voegelin, that modern organizations and modern organization theory should seek to re-awaken the lost experiences of the divine Beyond by re-animating religious symbols and myths of transcendence as devices for a spiritually opened consciousness. (shrink)

In light of the ongoing validity crisis in psychiatric classification, phenomenologically oriented psychiatric study has gained traction. This paper assesses two modes of investigation proposed by phenomenologists in studying mental disorders: the ideal type approach and the essential type approach. Despite the recent suggestion that they are antithetical approaches, I argue that they should constantly constrain and inform each other. In short, I advance a mutual complementarity thesis. Having established this thesis, I conclude by demonstrating how this proposal can function (...) as an heuristic strategy for effectively facilitating the recently proposed psychiatric research initiative, i.e. the ontological project of phenomenological psychopathology. (shrink)

This article presents a new account of the relationship between Michel Foucault’s work and neoliberalism, aiming to show that the relationship is significantly more complicated than either Foucault’s critics or defenders have appreciated in the recent controversy. On the one hand, I argue that Foucault’s salutary response to some of Gary Becker’s ideas in the lecture course from 1979 should be read together with the argument of Discipline and Punish. By means of this contextualization I show that Foucault’s sympathetic response (...) to Becker is limited to the domain of penal practices, specifically concerning the question of how to resist their rationality of normalization, and thus it involves no broader commitment to neoliberal economic theory or its political implications. On the other hand, however, I argue that there is a strategic allegiance between Foucault’s work and the ascendance of the neoliberal rationality of governing, although it has nothing to do with his sympathetic engagement with Becker’s work. Instead, I explain how Foucault’s focus on the political stakes of subjectivity has helped to congeal, in the posthumous neoliberal context, a conception of politics that leaves out the topic of economic equality. To explain how Foucault’s work has had this unintended yet lasting effect, I introduce the concept of topical exclusion. It designates a social mechanism of producing ignorance, which operates by directing attention instead of creating false consciousness. The strategic relationship between Foucault’s work and neoliberalism today illustrates that this type of explanation is essential in the analysis of power relations. Thus, my account motivates the adoption of topical exclusion as a conceptual supplement that equips the Foucaultian framework to study cases in which relations of power harness, produce, and sustain ignorance, not knowledge. (shrink)

This essay offers a novel interpretation of Michel Foucault’s original and often misunderstood conception of philosophy as a critical activity. While it is well known that Foucault’s critique undertakes to disclose contingent limits of thought that appear necessary in the present, the nature of the obstacle whose overcoming critique is meant to facilitate remains poorly understood. I argue that this obstacle, “the present limits of the necessary,” resides on the unconscious level of thought Foucault identified as the object of analysis (...) for an archaeology of knowledge. Therefore, Foucault’s conception of a critique can be grasped only against the background of the distinctive conception of thought that informs his archaeological analyses of discursive practices. According to that view, thinking is always shaped by some historically specific system of unconscious norms that define the contingent set of conceptual possibilities subjects are able to recognize in the present. Drawing on Foucault’s largely neglected remarks on the obvious and the habitual, I argue that these unconscious norms of thought are enacted habitually in a discursive practice, which endows them with an appearance of obviousness. In this way, I explain how something contingent appears in the guise of necessity and begins to function as part of the present limits of the necessary. Finally, I argue that the task of a critique to expand the scope of conceptual possibility by disclosing these unconscious limits of thought is motivated by Foucault’s commitment to the ideal of autonomy understood as subject’s self-determination. (shrink)

Within contemporary discussions on organizational wisdom, management scholars frequently turn to Aristotle’s work to conceptualize wisdom as phronesis, or practical wisdom. Contrary to the prevailing view, this paper argues that Aristotle did not propose an exclusively practical or particularistic conception of wisdom but, instead acknowledged that wisdom broadly conceived consists of two types of intellectual virtue: theoretical wisdom and practical wisdom. Aristotle’s ultimate position regarding the relations between sophia and phronesis has remained, however, ambiguous, giving rise to different interpretations, and, (...) more substantively, to the major appropriations of Aquinas, Heidegger and Gadamer. An analysis of the philosophical underpinnings of exemplary contributions to management wisdom suggests that research has predominantly applied Heideggerian and Gadamerian understandings of Aristotelian wisdom, while an Aquinian interpretation is largely absent in contemporary elaborations. Interpreting the Aristotelian notion of wisdom as dedicated purely to practical phronesis narrows the discussion on the nature of wisdom within an Aristotelian framework in ways that do not give full credit to the breadth and complexity of Aristotle’s thought. (shrink)

Delusional mood is a well-recognized psychological state, often present in the prodromal stage of schizophrenia. Various phenomenological psychopathologists have proposed that delusional mood may not only precede but also contribute to the later formation of schizophrenic delusion. Hence, understanding experiential abnormalities involved with the delusional mood have been considered central for the understanding of schizophrenic delusion. Ranging from traditional and contemporary phenomenological and neurobiological accounts, it has been often mentioned that the peculiar affective saliency of the world experience may underpin (...) the emergence of delusional mood. In this paper, I employ Edmund Husserl’s account of affection and affective syntheses to clarify the nature of such an experience and illuminate how this experiential abnormality contributes to the emergence of the delusional mood. I conclude by relating the phenomenological account I advance here with a neurobiological account of aberrant salience hypothesis and chart out a possible way toward mutual enlightenment for both approaches. (shrink)

In recent decades, the boundaries of democratic polities have been increasingly contested in the field of democratic theory. The theoretical discussion has focused on the philosophical norms that should demarcate the boundaries of democratic constituencies. This article defends and explores an alternative approach that, instead of focusing solely on theoretical norms, theorizes democratic processes of boundary-making. This alternative approach addresses the multiplicity of intertwined boundaries bounding demos and agents capable of transforming and democratizing these multiple boundaries. I characterize a category (...) of agents who democratize symbolic everyday boundaries as transboundary associations. The democratization of the symbolic boundaries of everyday interactions is a necessary condition for the democratization of formal boundary-making, since in democratic orders and societies, institutions cannot simply impose boundaries on people. Transboundary associations produce sites for incipient democratic politics that transcend current institutional and symbolic boundaries, producing possibilities for reciprocal boundary-making. (shrink)

Être transgenre implique des relations uniques à son propre corps, ainsi que la question du récit dans la formation du sujet – deux thèmes-clés chez Merleau-Ponty. Mais même si l’on accepte d’aller au-delà de l’histoire stéréotypée d’être « pris·e dans le mauvais corps », tant dans les communautés trans que dans le discours public plus large il existe une tendance fâcheuse à universaliser de tels récits – et ce, en dépit de l’hétérogénéité apparente que l’on retrouve dans les descriptions individuelles (...) à la première personne. La question émerge donc à savoir : comment rendre compte philosophiquement de cette différence à la première personne tout en visant une politique de solidarité? Cet essai cherche à utiliser la phénoménologie de Merleau-Ponty dans un sens pratique, en se concentrant sur sa description du « schéma corporel » pour atténuer cette tension. En effet, tandis que Merleau-Ponty nous fournit un ensemble général d’instruments pour comprendre la relation entre incarnation et comportement, ses exemples phénoménologiques sont souvent fortement singuliers. De la sorte, dans le contexte des subjectivités transgenres, le but est de creuser davantage cet espace discursif, comme prologue pour une praxis qui soit plus réceptive à l’expérience vécue des personnes trans. (shrink)

INTRODUCTION JEAN-MICHEL GANTEAU AND SUSANA ONEGA The rise of trauma theory in the critical field is a recent phenomenon associated with the revival of ...

We need to reflect upon the historical origins of organizing that extend far further than people usually think. This reflection must be critical and open to alternative histories and explanations. Origins of Organizing does just that. This book offers fascinating insights not only for those interested in organization and management history or critically oriented management and organizational studies, but for anyone engaged with organization theory or management practice, seeking for a deeper understanding of what organizing is all about. This is (...) because the book is compiled and written in a reflexive manner that does not offer one truth but a number of perspectives that help to enrich our understanding of organizing and its various origins.'"-- Eero Vaara, Aalto University School of Business, Finland. (shrink)

This paper defends Michel Foucault’s notion of archaeology of knowledge against the influential and putatively devastating criticism by Dreyfus and Rabinow that Foucault’s archaeological project is based on an incoherent conception of the rules of the discursive practices it purports to study. I argue first that Foucault’s considered view of these rules as simultaneously implicit and historically efficacious corresponds to a general requirement for the normative structure of a discursive practice. Then I argue that Foucault is entitled to that view (...) despite the charges to the contrary by Dreyfus and Rabinow. I also explain in detail how the argument by Dreyfus and Rabinow arises from a misunderstanding of Foucault’s archaeological project as transcendental inquiry, while archaeology of knowledge is, in fact, a diagnostic project. The result is a novel understanding of the notion of archaeology of knowledge that enables a reassessment of Foucault’s philosophical work in connection with current debates regarding the relationship between reflection and practice in the structure of thought. (shrink)

According to the received view, Marxian (ideology) critique and Foucaultian (genealogical) critique constitute two divergent approaches of critical theory that have remarkably different goals and little in common. In this article, however, we identify a guiding thread that connects the Marxian and Foucaultian traditions and motivates a distinctive approach within critical theory we call the ‘critique of constitution’. The problem of restricted consciousness, we show, is the core problem in common between Michel Foucault's critical history of thought and Georg Lukács's (...) theory of reification which underlies the tradition of Western Marxism and Frankfurt School critical theory. The problem concerns the limits of intelligibility and, by the same token, the apparent inevitability of the given social ontology. Our sense of what is possible depends on what we are able to think. But we know from the history of sciences that the limits of intelligibility change, thereby also altering our sense of what is possible. This becomes a political problem in connection with the intelligibility of social reality, because our restricted consciousness limits the alternatives we can so much as consider and seek to bring about. The critique of constitution, then, aims to expand the scope of possibility by revealing the contingent formation of the given limits of intelligibility. We argue that this is the paramount political task for Foucault and Lukács alike, other important differences notwithstanding. (shrink)

The extent of harm and suffering caused by the coronavirus pandemic has prompted a debate about whether the epidemic could have been contained, had the gravity of the crisis been predicted earlier. In this paper, the philosophical debate on predictive reasoning is framed by Hume’s problem of induction. Hume argued that it is rationally unjustified to move from the finite observations of past incidences to the predictions of future events. Philosophy has offered two major responses to the problem of induction: (...) the pragmatic induction of Peirce and the critical rationalism of Popper. It is argued that of these two, Popper’s critical rationalism provides a more potent tool for preparing for unanticipated events such as the Covid-19 pandemic. Popper’s notion of risky predictions equips strategic foresight with clear hypotheticals regarding potential crisis scenarios. Peirce’s pragmatic induction, instead, leans on probabilities that are slower to be amended as unexpected events start unfolding. The difference between the two approaches is demonstrated through a case study of the patterns of reasoning within the World Health Organization in the early stages of the coronavirus pandemic. (shrink)

This paper presents a new argument to defend the normativity of meaning, specifically the thesis that there are no meanings without norms. The argument starts from the observation inferentialists have emphasized that incompatibility relations between sentences are a necessary part of meaning as it is understood. We motivate this approach by showing that the standard normativist strategy in the literature, which is developed in terms of veridical reference that may swing free from the speaker’s understanding, violates the ought-implies-can principle, but (...) ours does not. In addition, our approach is superior because, unlike the representationalist approach, it can be extended from declarative sentences to non-representational uses of language. In this paper, however, we only formulate the argument for the base case that involves incompatibility relations between declarative sentences. The goal is not to derive norms from something that is not normative, but to explicate the distinctive type of normativity that is built into meaning as it is understood by language-users. The explication proceeds in two steps. (1) For any sentence s a speaker understands, there is an incompatible sentence s’ the speaker understands to be incompatible with s. (2) In virtue of understanding this incompatibility of meanings, she ought not to be committed to both s and s’. This prohibition is not derived from instrumental practical reason, nor is it based on representational correctness, but its source is the incompatibility of meanings. (shrink)

This paper presents a new interpretation of Michel Foucault’s critical project. It is well known that Foucault’s genealogical critique does not focus on issues of justification, but instead tackles “aspectival captivity,” that is, apparently inevitable limits of thought that constrain the agent’s freedom but that, in fact, can be transformed. However, it has not been recognized that, according to Foucault, critique can proceed along two distinct paths. In a key passage of “What Is Critique?,” Foucault states that critique is tasked (...) with questioning truth about its effects of power and with questioning power about its discourses of truth. We show that this “double movement” organizes Foucault’s critical project as a whole, giving it a significantly wider scope and a more complex structure than has been previously acknowledged. At the heart of the above-mentioned bifurcation lies an apparent tension between two contrastive roles Foucault assigns to truth-telling in the context of critique: on the one hand, truth-telling (as avowal) is a target of critique; on the other, truth-telling (as parrhesia) is one of critique’s methods. We argue that combining these two dimensions in a unified account is crucial for understanding and re-evaluating Foucault’s critical project as a whole. By showing that truth-telling remains an essential element of Foucauldian critique, this paper also rectifies some influential misinterpretations according to which Foucault’s critical project seeks to eliminate truth from the picture. (shrink)

This research was focused on investigating why some consumers might support cause-related marketing campaigns for reasons other than personal benefit by examining the influence of moral emotions and cultural orientation. The authors investigated the extent to which moral emotions operate differently across a cultural variable (US versus Korea) and an individual difference variable (self-construal). A survey method was utilised. Data were collected from a convenience sample of US ( n = 180) and Korean ( n = 191) undergraduates. Moral emotions (...) significantly influenced purchase intention for a social-cause product. The influence of an ego-focused moral emotion (i.e., pride) on purchase intention was greater for US than Korean participants. The influence of another-focused moral emotion (i.e., guilt) on purchase intention was greater for high-interdependent participants than for low-interdependent participants. The findings of this research provide important and relevant implications to marketers and policy makers in developing persuasive messages and customer relationship programmes. (shrink)

This chapter deals with medieval logic from the time when it first had full resources for systematic creative contributions onward. It focuses on the era when the ancient heritage was available and medieval logic was able to add something substantial to it, even to surpass it in some respects. The chapter explains that characterization such as this cannot be adequately expressed with years or by conventional period denominations; however, it is hoped that the grounds for drawing boundaries will become clearer (...) during the course of the story. (shrink)

The purpose of our article is to present a qualitative empirical study from the ethical viewpoint. It aims at the theoretical conceptualization concerning the managers' decision-making of personnel dismissals in downsizing organizations. First we present and seek to motivate our research task. The importance of real business ethical issues as a starting point of business ethics research is emphasized. Second the main normative ethical theories and ethical decision-making models are presented. These form the loose framework for describing and interpreting research (...) interviews. After this the empirical findings are set forth. This part suggests that the managers explain the dismissals from different decision-making roles emphasizing different ethical orientation. The roles are called a rational and an independent manager, a marionette and an emotional individual. Our study suggests that the role of empathy in morality reveals an interesting and a necessary research topic for business ethics research. (shrink)

The main concern of this paper is the moral responsibility of the firm, as well as of the individuals in a firm, to uphold environmental protection. Much of the business ethics literature defines corporate social responsibility in terms of stakeholder relationships, and the emphasis is frequently on collective as opposed to individual responsibility. This paper has three objectives. The first is to clarify the nature of moral responsibility, and the distinction between legal and moral responsibility. The second objective is to (...) steer academicians and others towards a new vision of the firm. We argue that a firm is not just a singular legal entity but also a collectivity of morally responsible individuals who are liable for immoral acts of the firm. By expanding the boundary of responsibility of action from an intangible collectivity – the firm, to all the individuals within it, this vision moves beyond the typical emphasis on the firm as being the only moral agent responsible for corporate actions. The paper emphasizes not simply the responsibility of top echelon managers, but of every employee across ranks. The third goal of this paper is to examine the circumstances where application of moral responsibility becomes crucial, for instance, in the context of protection of the natural environment by a firm and its employees. (shrink)

Asian workplaces are often characterized by cultures that require more overtime than other cultures. Although predictors for overtime work have been rigorously studied, it is still meaningful to investigate specific aspects of Eastern cultural values that stem from Confucian ethics and may influence overtime work among Asian employees. We suggest that four major Confucian orientations are positively associated with employees’ affective and normative motives, which in turn affect working overtime. This article extends management literature on the subjects of cultural ethics (...) and workaholism. It also suggests how Eastern cultural values lead to working overtime. We hope that our research effort on Confucian cultural value and its associations with other managerial outcomes and theories is a small cornerstone that allows management researchers to explore interesting and meaningful ways to apply Confucian culture and orientations in the workplace. (shrink)

The main concern of this paper is the moral responsibility of the firm, as well as of the individuals in a firm, to uphold environmental protection. Much of the business ethics literature defines corporate social responsibility in terms of stakeholder relationships, and the emphasis is frequently on collective as opposed to individual responsibility. This paper has three objectives. The first is to clarify the nature of moral responsibility, and the distinction between legal and moral responsibility. The second objective is to (...) steer academicians and others towards a new vision of the firm. We argue that a firm is not just a singular legal entity but also a collectivity of morally responsible individuals who are liable for immoral acts of the firm. By expanding the boundary of responsibility of action from an intangible collectivity – the firm, to all the individuals within it, this vision moves beyond the typical emphasis on the firm as being the only moral agent responsible for corporate actions. The paper emphasizes not simply the responsibility of top echelon managers, but of every employee across ranks. The third goal of this paper is to examine the circumstances where application of moral responsibility becomes crucial, for instance, in the context of protection of the natural environment by a firm and its employees. (shrink)

This paper investigates why some legislators tend to switch parties frequently while others tend to stay put. On the assumption that the ultimate goal of legislators is to be reelected, I argue that voters' demands for local/individual benefits, or pork, and legislators' lack of access to resources for such benefits are likely to lead the legislators to switch parties in order to improve their electoral chances in the subsequent election. By analyzing party switches by legislators from 1988 to 2008 in (...) South Korea, where the president controls access to the pork pipeline, I find that the president's party members are less likely and independents are more likely to change party affiliations, irrespective of voter demands for pork or national public policies. However, I also find that opposition party legislators who are elected from less-developed districts, where voters tend to desire pork over policy, are more likely to switch parties than those elected from more-developed districts. These findings suggest that interaction between voter demands and party access to resources influences politicians’ party loyalty: voter demands for pork (or policy) tend to lead politicians to be less (or more) loyal to their current parties. Voter demands, however, have little impact on the party loyalty of those who are already in parties with access to the pork pipeline. (shrink)

Prior studies assert that social trust may positively influence the economic performance of countries and firms (within those countries). This paper proposes a more nuanced mechanism whereby corporate social responsibility (CSR) mediates the relationship between country-level social trust and firm-level financial performance. Anchored in neo-institutional theory, we theorize that social trust instills norms of trustworthiness and willingness to trust others guiding individual and corporate behaviors. In order to comply with such norms and gain legitimacy, firms in high-trust society are more (...) likely to commit to CSR activities that serve the interests of stakeholders. CSR activities, in turn, can positively influence financial performance by enabling firms to access stakeholders' resources and capabilities and to decrease transactions costs in the stakeholder relationships. We tested our theory by analyzing 9818 firm-year observations across 34 countries, during the 2006 to 2015 period. Our analysis shows the expected CSR mediation in the relationship between social trust and firm-level financial performance. Our findings are robust across different models addressing the concerns of endogeneity, alternative measures, and potential moderators. (shrink)

Recent scandals allegedly linked to CEO compensation have brought executive compensation and perquisites to the forefront of debate about constraining executive compensation and reforming the associated corporate governance structure. We briefly describe the structure of executive compensation, and the agency theory framework that has commonly been used to conceptualize executives acting on behalf of shareholders. We detail some criticisms of executive compensation and associated ethical issues, and then discuss what previous research suggests are likely intended and unintended consequences of some (...) widely proposed executive compensation reforms. We explicitly discuss the following recommendations for reform: require greater independence of compensation committees, require executives to hold equity in the corporation, require greater disclosure of executive compensation, increase institutional investor involvement in corporate governance (including executive compensation), and require firms to expense stock options on their income statements. We provide a brief summary discussion of ethical issues related to executive compensation, and describe possible future research. (shrink)

Through corporate social responsibility activities, a firm can develop the capability for managing and benefiting from stakeholder relationships. This study refers to such a capability as stakeholder influence capacity. In a host country, locally sourcing parts and/or materials can generate economic value and improve social welfare. Moreover, local sourcing provides opportunities for a foreign firm to apply and advance SIC while closely interacting with host-country stakeholders. Accordingly, we expect that a firm, having gained SIC through CSR activities in its home (...) country, will be more likely to source parts and/or materials in the host country. We also expect that the relationship between SIC and host-country sourcing is conditional upon a foreign firm’s intangible resources and liabilities of foreignness. Our empirical analysis, using Korean datasets, supports the positive relationship between CSR and local sourcing. We find that this positive relationship is more pronounced either when the firm is committed to technology development or when its home and host countries are geographically or culturally distant. (shrink)

Clinical success with human hematopoietic stem cell (HSC) transplantation establishes a paradigm for regenerative therapies with other types of stem cells. However, it remains generally challenging to therapeutically treat tissues after engineering of stem cells in vitro. Recent studies suggest that stem and progenitor cells sense physical features of their niches. Here, we review biophysical contributions to lineage decisions, maturation, and trafficking of blood and immune cells. Polarized cellular contractility and nuclear rheology are separately shown to be functional markers of (...) a hematopoietic hierarchy that predict the ability of a lineage to traffic in and out of the bone marrow niche. These biophysical determinants are regulated by a set of structural molecules, including cytoplasmic myosin‐II and nuclear lamins, which themselves are modulated by a diverse range of transcriptional and post‐translational mechanisms. Small molecules that target these mechanobiological circuits, along with novel bioengineering methods, could prove broadly useful in programming blood and immune cells for therapies ranging from blood transfusions to immune attack of tumors. (shrink)